Ephrin Receptor

Ephrin Receptor Related Products (38):

By Effects:	Inhibitors (24) Agonists (6) Antagonists (5)

Cat. No.	Product Name	Effect	Purity

HY-18007

ALW-II-41-27	Inhibitor	99.33%
ALW-II-41-27 is a Eph family tyrosine kinase inhibitor with an IC₅₀ of 11 nM for Eph2.

HY-13258A

NVP-BHG712	Inhibitor	99.71%
NVP-BHG712 is an oral active EphB4 kinase autophosphorylation inhibitor, with IC₅₀ values of 3.3 nM and 3.0 nM for EphA2 and EphB4, respectively.

HY-18833

ALW-II-49-7	Inhibitor	99.97%
ALW-II-49-7 is a selective EphB2 kinase inhibitor with an EC₅₀ value of 40 nM in cell.

HY-18832

AWL-II-38.3	Inhibitor	99.71%
AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf.

HY-107460

LDN-211904 oxalate	Inhibitor	99.0%
LDN-211904 oxalate is a potent and reversible EphB3 inhibitor with an IC₅₀ of 79 nM. LDN-211904 oxalate shows good metabolic stability in mouse liver microsomes. LDN-211904 oxalate with Cetuximab (HY-P9905) could be effective in inhibiting STAT3-activated colorectal cancer (CRC) stemness and Cetuximab resistance in CRC.

HY-P991975

Anti-EphB3 Antibody	Inhibitor
Anti-EphB3 Antibody is an anti-EphB3 antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991965

Anti-Ephrin-B2 Antibody	Inhibitor
Anti-Ephrin-B2 Antibody is an anti-Ephrin-B2 antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-10654

EphB4-IN-2	Inhibitor
EphB4-IN-2 (compound 66) is a tyrosine kinase inhibitor with an IC₅₀ value of 1.6 nM against human EphB4, and exhibits selectivity toward kinases bearing threonine gatekeeper residues. EphB4-IN-2 also has high ligand efficiency.

HY-P990627

Anti-EphA2 Antibody (1C1)	Inhibitor	99.9%
Anti-EphA2 Antibody (1C1) (MEDI-547 antibody) is an anti-EphA2 monoclonal antibody. Anti-EphA2 Antibody (1C1) can induce degradation of EphA2 protein. Anti-EphA2 Antibody (1C1) conjugated with McMMAF (HY-15578) can form an antibody-conjugated drugs, which has potent antitumor activity. Anti-EphA2 Antibody (1C1) can be used for the research of cancer, such as prostate cancer and glioma.

HY-P0177

123C4	Agonist	99.46%
123C4 is a potent, selective and competitive agonist of the receptor tyrosine kinase EPHA4, with a K_i value of 0.65 μM.

HY-13258

NVP-BHG712 isomer		99.32%
NVP-BHG712 isomer, a regioisomer of NVP-BHG712, shows conserved non-bonded binding to EPHA2 and EPHB4.

HY-123607

UniPR129	Antagonist	99.23%
UniPR129 is a potent and orally active Eph/ephrin antagonist. UniPR129 can inhibit EphA2-ephrin-A1 interaction with an IC₅₀ of 945 nM and a K_i of 370 nM. UniPR129 can inhibit angiogenesis and show antitumor and neuroprotective effect. UniPR129 can be used for the researches of cancer and neurological disease, such as colorectal cancer and optic neuropathy.

HY-114199

Eph inhibitor 1	Inhibitor	99.92%
Eph inhibitor 1 is a potent Eph inhibitor. Eph inhibitor 1 has the potential for the research of neurological disorders.

HY-169849

EphA2 antagonist 1	Inhibitor
EphA2 antagonist 1 (4b) is a bile acid conjugate and an ephrin type-A receptor 2 (EPHA2) inhibitor.

HY-147637

EphA2 agonist 1	Agonist	98.57%
EphA2 agonist 1 (Compound 7bg) is a potent EphA2 receptor agonist. EphA2 agonist 1 shows great potency and selectivity toward EphA2 overexpressed glioblastoma cells and stimulates EphA2 phosphorylation.

HY-P3717

Targefrin		99.80%
Targefrin is a potent EphA2-targeting agent, acts as an antagonist. Targefrin binds EphA2-LBD with 21 nM dissociation constant and an IC₅₀ value of 10.8 nM. Targefrin induces cellular receptor internalization and degradation in several pancreatic cancer cell lines.

HY-P2264

KYL peptide	Inhibitor	99.65%
KYL peptide, an antagonistic peptide, selectively targets EphA4 receptor (IC₅₀:4.22 μM, Kd:1.3 μM). KYL peptide binds to the ligand-binding domain of EphA4, effectively alleviates Aβ-induced synaptic dysfunction and synaptic plasticity defects in AD mice. KYL peptide can promote nerve regeneration after injury and modulating immune responses.

HY-P990405

Anti-EphB2 Antibody	Inhibitor	99.36%
The Anti-EphB2 Antibody is a CHO expressed human antibody that targets EphB2. The Anti-EphB2 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-EphB2 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-131005

Eph inhibitor 2	Inhibitor	99.00%
Eph inhibitor 2 (Example 35) is a Eph family tyrosine kinase inhibitor.

HY-157019

UniPR1447	Antagonist	99.46%
UniPR1447 is Dual EphA2 and EphB2 antagonist, with an IC₅₀ of 6.6 μM for EphA2−ephrin-A1 binding.

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